Whether you’re craving a late-night snack, planning a midnight meal with friends, or just need a quick bite after a night out, Cape Girardeau has plenty of great options. Our Late-Night Dining Guide is updated for 2025 with the latest kitchen and business hours, so you can find open restaurants after 10 PM, midnight, and even later. Check out where to grab a meal when the rest of the city is winding down.
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Abelardo’s Mexican Fresh – Mexican food with fast service; open daily until at least 10 PM, later on weekends.
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Chili’s Grill & Bar – American grill and bar; open until 10 PM Sunday–Thursday, 11 PM Friday–Saturday.
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Culver’s – Burgers, custard, and comfort food; open until 10 PM daily.
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Dairy Queen (Grill & Chill) – Ice cream and fast food; open until 10 PM daily.
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Dogwood Social House – Arcade, bowling, and kitchen open until 11 PM Wednesday–Thursday and Sunday; later on weekends.
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Ebb & Flow Fermentations – Craft brewery and kitchen; open until 10 PM Friday–Saturday.
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El Acapulco – Traditional Mexican restaurant; open until 10 PM daily.
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Fazoli’s – Fast casual Italian; open until 10 PM Sunday–Thursday, 11 PM Friday–Saturday.
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Good Time Daiquiris – Frozen daiquiris and snacks; open until 10 PM Thursday, later on weekends.
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Andy’s Frozen Custard – Frozen treats; open until 11 PM Sunday–Thursday, 11:30 PM Friday–Saturday.
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Buffalo Wild Wings – Wings and sports bar; open until 11 PM Sunday–Thursday, 12:30 AM Friday–Saturday.
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Dogwood Social House – Entertainment venue; open until 11 PM most nights, later on weekends.
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Ebb & Flow Fermentations – Open until 11 PM Friday–Saturday.
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Fazoli’s – Open until 11 PM Friday–Saturday.
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Good Time Daiquiris – Open until 12 AM Friday–Saturday.
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Logan’s Roadhouse – Steakhouse and casual dining; open until 11 PM Friday–Saturday.
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Olive Garden – Italian-American cuisine; open until 11 PM Friday–Saturday.
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Applebee’s Grill & Bar – Casual American; open until 12 AM nightly.
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Buffalo Wild Wings – Open until 12:30 AM Friday–Saturday.
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Dogwood Social House – Open until 12 AM Friday–Saturday.
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Good Time Daiquiris – Open until 12 AM Friday–Saturday.
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Imo’s Pizza – St. Louis-style pizza; open until 12 AM Sunday–Thursday, 1 AM Friday–Saturday.
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Blue Diamond Sports Bar – Downtown sports bar; open until 1:30 AM daily.
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Dogwood Social House – Open until 1 AM Friday–Saturday.
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Hotshots Sports Bar & Grill – Wings and bar food; open until 1:30 AM Monday–Saturday.
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Huddle House – Diner-style eats; open 24 hours Friday–Saturday, closing early on weekdays.
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IHOP – Breakfast anytime; open 24 hours Friday–Saturday.
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Imo’s Pizza – Open until 1 AM Friday–Saturday.
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Abelardo’s Mexican Fresh – Mexican drive-thru; open until 2 AM Sunday–Wednesday, and until 3 AM Thursday–Saturday.
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Huddle House – 24/7 service on weekends.
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IHOP – 24/7 service on weekends.
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Insomnia Cookies (New) – Late-night cookies and delivery; open until 1 AM Sunday–Thursday and 3 AM Friday–Saturday.
(Hours verified via official websites and current as of April 25, 2025. Always consider calling ahead for the most up-to-date hours, especially on holidays.)
